Cheat Engine is an open source tool designed to help you with modifying single player games running under window so you can make them harder or easier depending on your preference(e.g: Find that 100hp is too easy, try playing a game with a max of 1 HP), but also contains other usefull tools to help debugging games and even normal applications.

It comes with a memory scanner to quickly scan for variables used within a game and allow you to change them, but it also comes with a debugger, disassembler, assembler, speedhack, trainer maker, direct 3D manipulation tools, system inspection tools and more.

For new users it is recommended to go through the tutorial(The one that comes with Cheat Engine, you can find it in your programs list after installing) and at least reach step 5 for basic understanding of the usage of Cheat Engine

If you need help on Cheat Engine , you can always contact me atdark_byte@hotmail.com , msn supported as well(don't ask about online games, I don't know anything about that)
Or on irc: server: irc.p2p-network.net channel: #cef (Web-based irc)

Local Cheat Engine WIKI